Courses PhD Program in Dentistry

Prof. Bruno Bueno-Silva – DDS, MSc, PhD.

Education and Professional Activities
Dr. Bueno-Silva received his DDS degree in 2005 from the Piracicaba School of Dentistry, Campinas State University, Brazil. He also received his Masters (2008) and PhD degrees (2012) in Dentistry, Pharmacology, Anesthesiology and Therapeutic area from the Piracicaba School of Dentistry, Campinas State University, Brazil. He also spent a PhD period (1 year) at Center of Oral Biology, University of Rochester at Rochester, NY, USA. Dr. Bueno-Silva has a Post-Doctoral Fellowship in Microbiology from University of Sao Paulo (USP). He is Full-time researcher and Instructor Professor in Dentistry at Guarulhos University (Brazil) and Volunteer Researcher at Piracicaba Dental School – Unicamp.

He is member of the International Association for Dental Research (IADR), and the IADR Microbiologt Research Group, Member of IADR Brazilian division (SBPqO), and ad-hoc reviewer of several international Journals such as Journal of Ethnopharmacology, Natural Products Research, BMC Oral health, etc.

Research Interests
His main research field is Natural Products biological effects with great emphasis on antimicrobial and anti-inflammatory properties of Brazilian propolis and its bioactive compounds. Other areas of research include: S. mutans biofilm, periodontal biofilm, cell culture, inflammation.

Other highlights
He has received some important awards, including honors in Oral Session of SBPqO in 2016; 2015; 2013; 2011; 2009; 2007 and 2006. In addition, his Ph.D. thesis were considered the best one of Piracicaba Dental School – Unicamp over the period 2012-2013.

Selected Peer-Reviewed Publications
Tiveron, A. P., Rosalen, P. L., Franchin, M., Lacerda, R. C. C., Bueno-Silva, B., Benso, B., Denny, C., Ikegaki, M., Alencar, S.M. (2016) Chemical characterization and antioxidant, antimicrobial, and anti-inflammatory activities of south Brazilian organic propolis. Plos One

Franchin, M., Morelo, D. F. C., Castanheira, F., Saraiva, A. L. L., Cunha, M. G., Bueno-Silva, B. , Alencar, S.M., Cunha, T. M., Rosalen, P. L. (2016) Neovestitol, an isoflavonoid isolated from Brazilian red propolis, reduces acute and chronic inflammation: involvement of nitric oxide and IL-6. Scientific Reports

Kawamoto, Dione, Ando-Suguimoto, Ellen S. Bueno-Silva, B., Dirienzo, Joseph, M., Mayer, M. (2016) Alteration of Homeostasis in Pre-osteoclasts Induced by Aggregatibacter actinomycetemcomitans CDT. Frontiers in Cellular and Infection Microbiology 7:1-10 .

Galvao, L. C. C., Rosalen, P. L., Franco, G. C. N., Rivera-Ramos, I., Kajfasz, J. K., Abranches, J., Bueno-Silva, B., Koo, H., Lemos, J. A. (2016) Inactivation of the or gene of decreases virulence in the rat caries model. Molecular Oral Microbiology 1

Bueno-Silva, B., Franchin, M., Alves, C. F., Denny, C., Morelo, D. F. C., Cunha, T. M., Alencar, S. M., Napimoga, Marcelo, H., Rosalen, P. L. (2016) Main pathways of action of Brazilian red propolis on the modulation of neutrophils migration in the inflammatory process. Phytomedicine (Stuttgart) 23:1583-1590 .

Bueno-Silva, B., Marsola, A., Ikegaki, M., Alencar, S. M., Rosalen, P. L. (2016) The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. Natural Product Research 4:1 -7 .

Franchin, M., Morelo, D., Castanheira, F., Cunha, M. G., Bueno-Silva, B., Alencar, S. M., Cunha, Mattar, T., Rosalen, P. L. (2016) Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. Journal of Natural Products 4:954-960.

Yang, M., Longo, P.L., Bueno-Silva, B., Mayer, M.P.A. (2015) Mechanisms involved in the association between periodontitis and complications in pregnancy. Frontiers in Public Health 2:290.

Bueno-Silva, B., Koo, H., Falsetta, M., Alencar, S., Ikegaki, M., Rosalen, P.(2013) Effect of Neovestitol-vestitol containing Brazilian red propolis on biofilm accumulation in vitro and dental caries development in vivo.  Biofouling  29:1233-1242.

Bueno-Silva, B., Alencar, S.M., Koo, H., Ikegaki, M., Silva, G.V., Napimoga, M.H., Rosalen, P.L. (2013) Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from brazilian red propolis. J Agric Food Chem  61:4546-4550.

Falsetta, M. L., Klein, M. I., Lemos, J. A., Bueno-Silva, B.,  Agidi, S., Scott-Anne, K.K., KOO, H. (2012) Novel anti-biofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo. Antimicrobial Agents and Chemotherapy (Online) 56:6201-6211.

Patente - Autores: Rosalen, P.L., Bueno-Silva, B., Alencar, S. M., Ikegaki, M., Koo, H. (2012) Composição contendo vestitol e neovestitol e seus usos.